Table V.
Results of univariate and multivariate cox proportional hazard model for biopsy-related active treatment-free survival
| Factorsa | Univariate cox model | Multivariate cox model | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |
| PSA density ≥0.12 ng/mL/cm3 | 2.2 | 1.66-2.83 | <0.0001 | 1.8 | 1.28-2.41 | 0.0006 |
| Prostate volume ≥50 cm3 | 0.4 | 0.34-0.58 | 0.0001 | 0.6 | 0.40-0.78 | 0.0007 |
| Maximum tumor involvement per biopsy core ≥10% | 1.6 | 1.23-2.06 | 0.001 | 1.5 | 1.09-1.96 | 0.0124 |
| Positive cores at diagnosis >1 | 1.5 | 1.17-1.99 | 0.001 | 1.6 | 1.18-2.09 | 0.002 |
| Number of cores at diagnosis ≥12 | 0.7 | 0.51-0.88 | 0.002 | 0.8 | 0.57-1.05 | 0.0978 |
| Age >66 y | 1.4 | 1.11-1.83 | 0.006 | 1.5 | 1.13-1.97 | 0.0055 |
| Clinical stage ≥T2a | 1.4 | 0.87-2.69 | 0.147 | |||
| PSA ≥8 ng/mL | 1.1 | 0.85-1.22 | 0.772 | |||
a
All factors were reduced to dichotomous variables following the cutoff values reported in the Table.
CI = confidence interval; HR = hazard ratio; PSA = prostate-specific antigen.