Table 3.
Estimated shigella burden in children younger than 5 years in low-income and lower middle-income countries
| AFRO | AMRO | EMRO | EURO | SEARO | WPRO | Global | |
|---|---|---|---|---|---|---|---|
| Demographics | |||||||
| Countries included in analysis | 38 | 6 | 11 | 7 | 9 | 8 | 79 |
| Population of children under 5 years of age | 148 767 015 | 6 453 900 | 61 254 753 | 8 316 736 | 174 938 512 | 23 036 247 | 422 767 163 |
| Total deaths | |||||||
| Number of deaths (thousands) | 30·1 (20·9–39·3) | 0·6 (0·4–0·7) | 21·1 (14·8–27·2) | <0·1 (<0·1–<0·1) | 11·2 (7·9–14·6) | <0·1 (<0·1–<0·1) | 63·1 (44·0–81·9) |
| Mortality rate (deaths per 100 000) | 20·3 (14·1–26·4) | 9·2 (6·3–11·6) | 34·4 (24·2–44·4) | 0·06 (0·04–0·08) | 6·4 (4·5–8·3) | 0·2 (0·1–0·2) | 14·9 (10·4–19·4) |
| Diarrhoea burden | |||||||
| Number of deaths (thousands) | 23·1 (16·9–30·1) | 0·5 (0·4–0·6) | 16·8 (12·2–21·9) | <0·1 (<0·1–<0·1) | 9·0 (6·6–11·8) | <0·1 (<0·1–<0·1) | 49·4 (36·1–64·5) |
| Mortality rate (deaths per 100 000) | 15·5 (11·3–20·3) | 7·7 (5·5–9·8) | 27·4 (20·0–35·7) | <0·1 (<0·1–0·1) | 5·2 (3·8–6·7) | 0·1 (<0·1–0·2) | 11·7 (8·5–15·3) |
| Morbidity (millions of episodes) | 41·3 (29·2–55·5) | 2·4 (1·7–3·2) | 38·1 (27·0–51·3) | <0·1 (<0·1–0·1) | 29·4 (20·8–39·5) | 0·2 (0·1–0·3) | 111·4 (78·8–149·9) |
| Morbidity rate (episodes per 1000) | 277 (196–373) | 365 (258–491) | 623 (441–838) | 5·6 (4·0–7·5) | 168 (119–226) | 8·8 (6·2–11·8) | 264 (186–355) |
| DALYs (thousands) | 1993 (1456–2600) | 45 (32–57) | 1458 (1065–1901) | 0·4 (0·3–0·5) | 797 (584–1042) | 2·8 (2·0–3·6) | 4297 (3140–5604) |
| DALYs (per 100 000) | 1340 (979–1748) | 695 (496–883) | 2381 (1739–3103) | 4·8 (3·5–6·3) | 456 (334–595) | 12·1 (8·8–15·7) | 1016 (743–1326) |
| Burden from other infectious disease-related deaths due to shigella-Induced stunting | |||||||
| Number of deaths (thousands) | 7·0 (2·4–10·7) | 0·1 (0·0–0·1) | 4·3 (1·5–6·4) | <0·1 (<0·1–<0·1) | 2·2 (0·7–3·3) | <0·1 (<0·1–<0·1) | 13·6 (4·6–20·7) |
| Mortality rate (deaths per 100 000) | 4·7 (1·6–7·2) | 1·4 (0·5–2·2) | 7·0 (2·4–10·5) | <0·1 (<0·1–<0·1) | 1·3 (0·4–1·9) | <0·1 (<0·1–<0·1) | 3·2 (1·1–4·9) |
| Increase in shigella-related burden due to shigella-induced stunting | 31% (11–43) | 19% (7–27) | 26% (9–36) | 22% (8–31) | 24% (9–34) | 20% (7–29) | 28% (10–39) |
| Additional cases of moderate-to-severe stunting (thousands) | 748 (254–1151) | 37 (12–56) | 753 (256–1159) | 0·7 (0·2–1·0) | 603 (205–927) | 3 (1–5) | 2144 (728–3299) |
| Additional cases of severe stunting (thousands) | 392 (133–603) | 16 (5–25) | 411 (140–632) | 0·3 (0·1–0·5) | 327 (111–502) | 1 (<1–2) | 1147 (390–1765) |
Data are episodes (95% UI). Episodes are the estimated number of diarrhoeal cases that children experience annually. AFRO=African region. AMRO=Region of the Americas. EMRO=Eastern Mediterranean Region. EURO=European Region. SEARO=Southeast Asian Region. WPRO=Western Pacific Region.