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. 2019 Feb 5;2019:2403793. doi: 10.1155/2019/2403793

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Copyright © 2019 Xiaotian Dong et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MSC transplantation improves intestinal histopathology and epithelial tight junctions (TJs). (a) Histopathology of the ileum of different experimental groups. (b) Relative expression of zonula occludens- (ZO-) 1 mRNA by real-time quantitative polymerase chain reaction. n = 4 per group; mean ± SD; t-test (^∗ p < 0.05). (c) Immunofluorescence analysis of ZO-1 distribution. (d) Ultrastructure of TJs using transmission electron microscopy. Oil: olive oil control; c: CCl₄-treated group; m: MSC-transplanted group. 48 h, 1 w, and 2 w indicate 48 hours, 1 week, and 2 weeks after CCl₄ treatment, respectively.