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. Author manuscript; available in PMC: 2020 Jan 28.
Published in final edited form as: J Control Release. 2018 Dec 18;294:237–246. doi: 10.1016/j.jconrel.2018.12.031

Figure 7.

Figure 7.

Effect of DDNDs loaded with miR-345 and GEM on tumorigenicity and metastasis (A) Changes in distant organs with metastatic lesions and pancreatic tumor tissue histology as a result of DDND mediated delivery of miR-345 and GEM. The first and second rows are the light microscopy images (100×) of H&E stained metastatic lesions from the control group. The third row shows H&E stained primary pancreatic tissue sections for each treatment group. (B) The number of animals showing incidence of metastasis at distant organs in the various treatment groups.