. Author manuscript; available in PMC: 2019 Oct 1.

Published in final edited form as: Bioorg Med Chem. 2018 Aug 20;26(18):4984–4995. doi: 10.1016/j.bmc.2018.08.020

Table 8.

Rat in vivo PK parameters of selected MMP-13 inhibitors.

Compd.	T_1/2 (h)	c_max(μM)	Cl (mL/min/kg)

2	2.9	47.6	0.18
28	2.6	59.4	0.25
30	2.8	75.6	0.16
31	3.0	56.8	0.23
32	2.4	56.9	0.22

Dose: IV, 1 mg/kg; formulation = 1 mg/mL in 10/10/80 DMSO/Tween 80/water.