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. 2019 Feb 19;14:6. doi: 10.1186/s12263-019-0630-1

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Metabolic features of mice. a, b The dynamic changes in body weights (a) and food intake (b) of mice fed ND and HFD for 12 weeks. c The dynamic changes in blood glucose in mice during IPGTT. d–l The changes in serum insulin (d), TC (e), TG (f), HDL-C (g), LDL-C (h), HOMA-IR (i), liver weights (j), liver TG content (Oil Red O staining) (k), and the expression of p-Akt, Akt, p-GS, GS, G6PC, PCK1, and β-actin proteins (l) in liver tissues in the two groups of mice. ND, normal diet mice; HFD, high-fat diet mice; *P < 0.05, **P < 0.01, compared with the value of the ND group