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. 2019 Feb 19;18:27. doi: 10.1186/s12943-019-0951-0

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Up-regulated circRNAs in BC tumor tissues and its correlation with prognosis of patients. a cTFRC increased in BC tissues as compared to that in the matched nontumor tissues analyzed by circRNAs Arraystar Chip. b Schematic representation of the high expression level of cTFRC in 57 BC patients tissues compared with adjacent normal patients tissues by qPCR. c cTFRC upregulated in recurrent BC patients. d The high expression levels of cTFRC in BC patients with high grade. e Advanced T stage is associated with higher cTFRC levels. f The expression of cTFRC higher in patients with lymphatic metastasis. g Prognostic significance of cTFRC expression for BC patients was performed with cTFRC values by using the median value as the cutoff