Table 3.
Summary of the PK Parameters of AZD7594 at Steady‐State (Day 14) by Dose Levels
| Geometric mean | AZD7594 | AZD7594 | AZD7594 |
|---|---|---|---|
| (CV%) | 58 μg | 250 μg | 800 μg |
| (n = 9) | (n = 9) | (n = 8) | |
| Cmax, ss (pmol/L) | 54.97 (19.70) | 158.7 (35.01) | 421.6 (37.26%) |
| AUC(0‐24) (h×pmol/L) | 467.1 (17.91) | 1725 (44.33) | 4894 (52.48%) |
| Cavg, ss (pmol/L) | 19.48 (17.93) | 71.89 (44.33) | 203.9 (52.55%) |
AUC(0‐24): area under the plasma concentration‐time curve from time zero to 24 hours after dose administration; Cavg,ss: average plasma concentration during a dosing interval at steady‐state; Cmax,ss: observed maximum plasma concentration at steady‐state; CV%: geometric coefficient of variation; n: number of patients in the PKS for each treatment