Fig. 2.

Change from baseline in the co-primary endpoints after 6 months of randomized treatment with 0.1% cyclosporine A cationic emulsion (CsA CE) in patients with moderate to severe dry eye disease. (A, B) Mean change from baseline in corneal fluorescein staining (CFS) and visual analogue scale (VAS) scores, respectively. A total of 241 patients and 248 patients in the CsA CE and vehicle groups, respectively, were analyzed. Data represent the full analysis set (FAS) with missing data imputed by the last observation carried forward method. The statistical comparison shown reflects the results of an analysis of covariance model, which was confirmed by logistic regression and Van Elteren test.