Table 1:

Characteristics of DWI Studies

Study/Subject	dMRI Protocol	Analysis	Findings
Helenius et al., 2001 [50] LA=85, HC=22, IS=10	Siemens 1.5T b=1000, D=3	Cross-sectional Regional	High ADC in WMHs and NAWM of severe LA than mild LA
Viana-Baptista et al., 2008 [52] LA=29	GE 1.5T b=1000, D=6	Cross- sectional Regional	Positive correlation of ADC with Age, BP, VSS and negative correlation with attention
Ropele et al., 2009 [53] LA=340	1.5T b=900–1000, D=3	Cross- sectional Histogram	ADC and not magnetization transfer ratio was related to WMH severity
Viana-Baptista et al., 2011 [54] LA=29	GE 1.5T b=1000, D=6	Cross- sectional Regional	Significant negative correlations between ADC and motor function
Oztoprak et al., 2015 [56] SVD=50, MS=35, HC=85	Siemens 1.5T b=1000, D=3	Cross- sectional Regional	High ADC in thalamus of S VD subjects than in MS and HC
Mascalchi et al., 2002 [51] LA=10	Philips 1.5T b=1000, D=3	Longitudinal Histogram	ADC increases, brain volume index decreases with disease progression; No change in GS, MMSE
Jokinen et al., 2013 [55] LA=340	1.5T b=900–1000, D=3	Longitudinal Histogram	ADC correlates with cognitive decline and disease progression.