Table 3.

Characteristics of Cross-sectional studies reporting DTI findings in SVD, SIVD and VCID

Study/Subject	dMRI Protocol	Analysis	Findings
Nitkunan et al., 2008 [64] SVD=29, HT=63, NT=42	GE 1.5T b=1000	Regional	High WMH volume in SVD; Higher MD, lower FA and lower NAA with disease progression;
Zhou et al., 2008 [65] VCI=19, PS=19, HC=19	Philips 3T b=800 D=15	Histogram	Lower FA in VCI and PS than HC; MMSE correlated with FA in VCI, whereas MMSE correlated with MD in PS and HC
Kim et al., 2011 [66] MCI=27, Dementia=34	GE 3T b=600 D=45	VBM	MD and FA are significantly correlated with cognitive and motor deficits
Huang et al., 2014 [68] SVD=12, HC=6	GE 1.5T b=1000	Regional	Significant difference between SVD and HC for MD but not for NAA, and weak but not significant differences in FA
Thong et al., 2014 [69] Mild VCI=25, Moderately severe VCI=30, AD=20 HC=25	Siemens 3T b=1150 D=61	VBA, Regional	Thinner cortex and lower volumes in all disease groups as compared to HC; Higher MD and lower FA in moderately severe VCI and AD than in HC; Only higher MD in mild VCI than HC;
Croall et al., 2017 [71] SVD=199	3T b=1000 D=32	Histogram	Significant correlations between DTI and number of lacunar infarcts with CS, but none between WMH volume and CS
Tu et al., 2017 [72] SIVD=35, AD=40, HC=33	GE 3T b=1000 D=20	Regional	Higher Fazekas scale and MD and lower FA and FABS in SIVD than in AD