Table 4.

Characteristics of longitudinal studies reporting DTI findings

Study/Subject	dMRI Protocol	Analysis	Findings
Nitkunan et al., 2008 [63] LA, at baseline=35, LA at one year=27	GE 1.5T b=1000 D=12	Histogram	Higher MD and lower FA, but no changes in WMH volume, brain volume, and CS between time points
Cavallari et al., 2014 [67] SVD=56	Siemens 3T b=1000 D=12	Regional	Baseline: Thalamus and putamen MD correlated with WMH volume; Follow-up: Thalamus FA correlated with annual WMH accrual rate over 4 years