. Author manuscript; available in PMC: 2020 Feb 16.

Published in final edited form as: Neurosci Lett. 2018 Dec 6;694:198–207. doi: 10.1016/j.neulet.2018.12.007

Table 5:

Characteristics of RUN DMC studies

Study	Analysis	Findings
Gons et al., 2010 [73]	Cross- sectional Regional	BP correlated with WMHs volume; High BP correlated with low FA and high MD; Lower FA and higher MD in HT than in NT
van Norden et al., 2012 [74]	Cross- sectional Regional	DTI correlated with CS in mild, moderate and severe WMHs; DTI had limited additional value as compared to WMHs volume with respect to correlations with cognitive decline
van der Hoist et al., 2013 [77]	Cross- sectional Regional, TBSS	DTI correlated with CS and hippocampal integrity; Higher MD associated with 5 year dementia risk
Tuladhar et al., 2015 [88]	Cross- sectional Regional, TBSS	DTI of genu and splenium correlated with CS; DTI of various WM tracts related to CS
van Uden Hoist et al., 2015 [78]	Longitudinal Regional	No significant relation between DTI and CS decline after adjusting for confounders; Higher MD associated with 5 year dementia risk
van Leijsen et al., 2018 [81]	Longitudinal Regional	WM damage can be detected by DTI before the appearance of WMH lesions.