Table 6:

Characteristics of studies belonging to SCANS study

Study	Analysis	Findings
Lawrence et al., 2013 [82]	Cross-sectional Histogram	DTI and number of lacunar infarcts correlated with CS decline; DTI suggested ischemic demyelination in SVD
Benjamin et al., 2016 [83]	Longitudinal Histogram	DTI and WMH volume had greater significance in predicting disease progression than CS
Zeestraten et al., 2016 [84]	Longitudinal Histogram	Histogram peak height of MD was the most sensitive marker for disease progression among all other DTI metrics
Williams et al., 2017 [85]	Longitudinal Histogram	A novel DTI segmentation method predicted cognitive decline over a 3 year period
Zeestraten et al., 2017 [86]	Longitudinal Regional	DTI markers and WMH volume correlated significantly with CS decline and predicted dementia over 3 years.