Table 8:

Characteristics of studies using tractography and diffusion based connectivity analysis

Study/Subjects	Diffusion Protocol	Analysis	Conclusions
Correia et al., 2008 [100] VCI=14, HC = 18	Siemens 1.5T DTI b=1000, D=12	Cross-sectional Connectivity Network Analysis	Significant correlations between network measures and cognitive scores
Lawrence et al., 2014 [101] LA = 115, HC=50	GE 1.5T DTI b=1000, D=25	Cross-sectional Connectivity Histograms	Reduced network connectivity in SVD. Network measures have stronger correlation with cognitive scores than with WMH volume
Kim et al., 2015 [102] VCI = 232	Phillips 3T DTI b=1000, D=45	Cross-sectional Connectivity Whole Brain	Network segregation correlated with cognitive scores and WMHV
Reijmer et al., 2016 [93] VCI = 232	Siemens 3T b=700	Cross-sectional Connectivity Whole Brain	FA correlated with cognitive scores in central brain regions
Tuladhar et al., 2016 [103] SVD = 436	Siemens 1.5T DTI b=900, D=30	Cross-sectional Connectivity Whole Brain	WMH volume and MD of WM correlates with cognitive scores
Tuladhar et al., 2016 [104] SVD = 436	Siemens 1.5T DTI b=900, D=30	Longitudinal Connectivity Whole Brain	Network efficiency predicts dementia
Metoki et al., 2017 [96] SVD = 106	GE 1.5T DTI b=1000, D=25	Cross-sectional Cingulum Uncinate fasciculus	Lower memory scores in SVD than HC MD correlated with memory scores FA only correlated with working memory
Lawrence et al., 2018 [105] SVD=26, HC=19	Siemens 3T DTI b=1000, D=63	Cross-sectional Connectivity Whole Brain ROIs	Lower network measures in SVD than HC Similar fMRI network measures in SVD andHC
Biesbroek et al., 2018 [94] VBI=159	Phillips 3T DTI b=1200, D=45	Cross-sectional Connectivity Whole Brain ROIs	Specific white matter tracts are strongly correlated with specific cognitive scores
D’Souza et al., 2018 [97] SVD=30	Siemens 3T DTI b=1000, D=30	Cross-sectional Connectivity Whole Brain ROIs	MD and FA are correlated with cognitive scores and no correlation with WMH volume
Lawrence et al., 2018 [106] SVD=97	GE 3T DTI b=1000, D=30	Longitudinal Network Connectivity Histogram	Network global efficiency during follow up correlated with increased dementia
Lisiecka-Ford et al., 2018 [107] SVD=114	GE 3T DTI b=1000, D=30	Cross-sectional Connectivity Whole Brain ROIs	Network efficiency of reward network negatively correlated with apathy scores.