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Auto-inhibition of the GAP activity is lost in p190A mutants - In the model of p190RhoGAP auto-inhibition, wild-type p190A (p190A WT) oscillates between a closed/inactive and an open/active form to ensure intermittent RhoA activity at the leading edge. PLS removal (deletion 380–800) and cancer-occurring point mutation (S866F) and deletion (deletion 865–870) maintain p190A in a constitutively active conformation that leads to enhanced and sustainable RhoA inactivation.
