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Schematic presentation of cross-presentation of exogenous antigen in dendritic cells. Rac2 assembles the NADPH oxidase at the phagosomal membrane leading to production of reactive oxygen species. The ATPase pumps out protons (H+) from the phagosome leading to a near neutral pH and antigen escape to the cytosol. Abbreviations: DC; dendritic cell, ROS; reactive oxygen species, TCR; T cell receptor.
