Figure 5.

TbRRP44 endonucleolytic site. (a) Superposition of TbRRP44 (orange) and ScRrp44 (blue, PDB 5K36) structures. TbRRP44 catalytic residues and the corresponding residues in ScRrp44 are shown in sticks and labeled. The residues forming the neighboring Zn interaction site in TbRRP44 (H69, N70 and H175) are also shown. The Mn ions bound to the TbRRP44 active site are represented as purple spheres while the Zn atom is shown in light grey. (b) Detail of the interactions involving the manganese ions. Water molecules are represented as red spheres. TbRRP44 catalytic residues and main chain (MC) atoms involved in the interactions are identified.