Table 1:

Transcription factors that when depleted increase CFTR mRNA levels ≥ 2 fold in Calu-3 cells.

GENE	CFTR/β2M Change*	Calu-3 FPKM**	HBE FPKM**
	ING2	3.00	7.38	10.10
ANKFY1	2.83	8.01	11.52
NR2F2	2.71	44.65	10.21
BRD8	2.58	37.76	9.47
KLF5	2.58	79.54	122.97
ZNF148	2.52	13.44	6.93
TCF7L2	2.45	22.52	4.15
TGIF1	2.41	47.48	38.61
VGLL1	2.39	80.18	9.71
TLE1	2.36	30.09	10.32
ANKRD54	2.34	16.48	24.21
EHF	2.32	72.53	189.09
SMARCC2	2.31	28.88	17.51
MDM2	2.30	14.84	35.66
BRCA1	2.29	8.00	2.89
ANKZF1	2.29	22.62	23.95
GTF2IRD1	2.28	11.93	24.06
ATF5	2.25	34.38	59.74
ECSIT	2.25	20.23	13.86
SATB2	2.24	1.146	2.69
SREBF2	2.23	131.37	67.47
HDAC1	2.19	206.77	42.60
SMARCE1	2.17	315.31	39.85
BTG1	2.16	52.28	34.37
PLRG1	2.14	36.62	21.04
IRF2BP1	2.13	15.08	7.32
RBAK	2.13	4.05	8.48
CASKIN1	2.13	5.51	5.59
FOXE1	2.11	1.21	5.26
GATAD2A	2.10	40.31	14.27
ZNF232	2.07	3.63	4.23
CDKN2B	2.07	63.80	16.03
TARBP1	2.05	9.47	11.10
TEAD4	2.05	21.13	1.91
NR1D1	2.04	23.90	22.81
ZNF33A	2.02	6.19	5.81
TAF4B	2.00	3.82	1.62

^*Denotes average of duplicate or

^**triplicate assays.

Highlighted factors were studied further.