Table 4.
Association between POPs principal components, ESRD, or death without ESRD in persons with type 2 diabetes.
| Model | 1 | 2 | 3 | 4 | 5 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Covariates: | None | Age sex | Age sex MAP | Age sex MAP cholesterol TG 2hPG | Age sex MAP eGFR TG cholesterol 2hPG | |||||
| ESRD | Hazard Ratio | 95% CI | Hazard Ratio | 95% CI | Hazard Ratio | 95% CI | Hazard Ratio | 95% CI | Hazard Ratio | 95% CI |
| PCB PC1 | 0.84 | 0.52–1.34 | 0.99 | 0.68–1.46 | 1.01 | 0.68–1.49 | 0.94 | 0.60–1.46 | 0.94 | 0.61–1.45 |
| PCB PC2 | 1.32 | 0.67–2.59 | 2.25 | 0.93–5.43 | 2.49 | 0.98–6.31 | 2.86 | 0.99–8.29 | 3.32 | 1.07–10.27* |
| PCB PC3 | 1.27 | 0.95–1.70 | 1.39 | 0.99–1.93 | 1.43 | 1.02–2.01* | 1.53 | 1.08–2.17* | 1.53 | 1.08–2.18* |
| PST PC1 | 0.86 | 0.55–1.34 | 1.06 | 0.65–1.71 | 1.06 | 0.66–1.72 | 0.95 | 0.50–1.79 | 0.94 | 0.50–1.77 |
| PST PC2 | 1.07 | 0.72–1.59 | 0.99 | 0.65–1.50 | 0.97 | 0.63–1.50 | 0.96 | 0.63–1.44 | 0.95 | 0.63–1.45 |
| Death | ||||||||||
| PCB PC1 | 1.16 | 0.97–1.38 | 0.97 | 0.69–1.36 | 1.05 | 0.76–1.46 | 1.21 | 0.91–1.61 | 1.20 | 0.91–1.59 |
| PCB PC2 | 2.91 | 1.85–4.58* | 1.47 | 0.83–2.61 | 1.68 | 0.93–3.01 | 6.30 | 2.56–15.45* | 8.11 | 3.11–21.18* |
| PCB PC3 | 0.75 | 0.50–1.11 | 0.81 | 0.59–1.11 | 0.86 | 0.61–1.21 | 0.93 | 0.66–1.30 | 0.91 | 0.65–1.29 |
| PST PC1 | 1.68 | 1.34–2.10* | 1.13 | 0.84–1.54 | 1.22 | 0.89–1.66 | 1.74 | 1.19–2.54* | 1.75 | 1.19–2.58* |
| PST PC2 | 0.65 | 0.50–0.83* | 0.79 | 0.59–1.05 | 0.78 | 0.57–1.06 | 0.66 | 0.46–0.95* | 0.65 | 0.45–0.93* |
*
Significant associations. Model 3 was chosen as the most parsimonious, including covariates that are significantly predictive. CI, confidence interval; eGFR, estimated glomerular filtration rate; ESRD, end-stage renal disease; 2hPG, 2-hour plasma glucose; MAP, mean arterial pressure; PC, principal component; PCB, polychlorinated biphenyls; POPs, persistent organic pollutants; PST, pesticides; TG, triglycerides.