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. 2019 Jan 15;14(2):266–275. doi: 10.1021/acschembio.8b00972

Figure 1.

Figure 1

Inhibition of LmFH isoforms by 2-thiomalate. (A) Structure of 2-thiomalate molecule. (B) FH catalytic reversible reaction of S-malate to fumarate. (C) Dose–response curve of the inhibition of mitochondrial LmFH-1 by RS-2-thiomalate against S-malate (3 mM). (D) Dose–response curve of the inhibition of mitochondrial LmFH-1 by RS-2-thiomalate against fumarate (3 mM). (E) Dose–response curve of the inhibition of cytosolic LmFH-2 by RS-2-thiomalate against S-malate (3 mM). (F) Dose–response curve of the inhibition of cytosolic LmFH-2 by RS-2-thiomalate against fumarate (6 mM). Error bars represent three independent measurements.