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Silencing EZH2 increased STAT6 ubiquitination through association with ITCH. A: NEAT1 bound to EZH2 in CD4+T cell extracts. B: ChIP analysis of EZH2 binding to the ITCH locus. C: The targeted antibody Ub- STAT6, ITCH and negative control IgG were used for the immunoprecipitation assay. Silencing EZH2 increased STAT6 ubiquitination.
