Figure 2.

Association between LINE-1 methylation and the first principle component (PC1) from the genome-wide PCA analysis (n = 572). PCA was performed on genome-wide SNP data generated using the Affymetrix Axiom Biobanking Array. All study participants are shown as filled circles. The blue line represents X. X is shown by the grey shading. Lower levels of European admixture are associated with higher levels of LINE-1 methylation (p-value = 0.0004). Individuals with lower levels of European admixture have higher values for PC1.