Fig. 2.

Genomic alterations frequently target the BCR signaling axis. (A) Members of the BCR signaling axis are frequently mutated. Shown are the mutation frequency of BCR pathway members in PCNSL as identified by different sequencing projects and includes only single nucleotide variants but no copy number alterations (y-axis: percent affected cases in each study, range: 9–177 patients; x-axis: genes affected by genomic alteration). (B) Cartoon of the BCR/NFκB signaling axis. Genes affected by frequent genomic alterations in PCNSL are highlighted with red asterisks. Targetable signaling nodes are highlighted.