Fig. 2.

Radiomics pipeline of the study. Part I includes image acquisition, registration, and segmentation. Signal intensity normalization is conducted for contrast-enhanced T1-weighted and fluid-attenuated inversion recovery imaging. Part II includes extraction of radiomics features. Part III includes feature selection and modeling, with special consideration for high-dimensional data. The diagnostic performance is then calculated with the selected radiomics features. CE-T1WI = contrast-enhanced T1-weighted imaging; ADC = apparent diffusion coefficient; CBV = cerebral blood volume; ROC = receiver operating characteristic curve.