Fig. 2.

MCAO surgery induced ischemic stroke. (a) 2,3,5-Triphenyltetrazolium chloride staining showed that the control and sham groups had uniform dark staining, whereas large white areas of infarction can be observed in the right cerebral hemispheres of the stroke group. (b) An obvious increase in infarction volume was detected in the right cerebral hemisphere of stroke rats who underwent MCAO surgery compared with the control and sham groups (mean±SD, n=10/group, one-way ANOVA). (c) Prominent neurological deficits were observed in the stroke rats compared with the control and sham groups (mean±SD, n=10/group, one-way ANOVA). ANOVA, analysis of variance; MCAO, middle cerebral artery occlusion. *P<0.05 versus the control group, ^#P<0.05 versus the sham group.