Skip to main content
. 2019 Feb 19;15(2):e8636. doi: 10.15252/msb.20188636

Figure 2. Disease state characterization using blood physiology and histopathology.

Figure 2

  1. Comparison of liver and kidney severity scores (top). Imputed severity scores shown in Fig 1D were grouped for each DS, and their median (point) and lower and upper quartiles (bar) are shown. X‐ and y‐axes correspond to liver and kidney severity scores, respectively. The number of samples per DS vary between 37 and 198. Non‐DS has 2,723 samples. Log ratio of liver over kidney severity scores (bottom).
  2. Changes in physiology parameters and DSs. Yellow/cyan indicates the parameters are higher/lower than control vehicle treatments in the DS. Thirty‐one parameters whose FDR‐adjusted P‐values < 1 × 10−10 (Wilcoxon two‐sample test) in ≥ one DS were shown.
  3. Histopathology phenotypes and DSs. Relative enrichment of a phenotype among DSs was shown. Yellow indicates more observations in a DS than the others. Thirty‐four histopathology phenotypes whose FDR‐adjusted P‐values < 5 × 10−3 (Fisher's exact test) in ≥ one DS were shown.