Table 2.
Risk of breast cancer and history of hypertension (HBP), high cholesterol, and diabetes in Chinese, Japanese, and Filipina Americans in Los Angeles County
| Chinese | Japanese | Filipina | All | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Ca | Co | OR1 (95%CI) | Ca | Co | OR1 (95%CI) | Ca | Co | OR1 (95%CI) | OR2 (95%CI) | |
| HBP | ||||||||||
| No | 689 | 724 | 1.00 | 349 | 362 | 1.00 | 468 | 402 | 1.00 | 1.00 |
| Yes | 191 | 161 | 0.87 (0.66, 1.14) | 167 | 140 | 0.99 (0.71, 1.37) | 303 | 177 | 1.34 (1.03, 1.76) | 1.11 (0.94, 1.30) |
| Lagtime4 | ||||||||||
| ≤10yrs | 120 | 106 | 0.86 (0.63, 1.18) | 98 | 83 | 0.96 (0.66, 1.41) | 199 | 97 | 1.66 (1.21, 2.28) | 1.18 (0.99, 1.42) |
| >10yrs | 71 | 55 | 0.89 (0.58, 1.35) | 69 | 57 | 1.03 (0.66, 1.62) | 104 | 80 | 0.94 (0.64, 1.36) | 0.98 (0.78, 1.23) |
| P trend5 | 0.39 | 0.95 | 0.43 | 0.61 | ||||||
| High Cholesterol | ||||||||||
| No | 668 | 723 | 1.00 | 330 | 368 | 1.00 | 544 | 441 | 1.00 | 1.00 |
| Yes | 212 | 162 | 1.21 (0.94, 1.56) | 185 | 134 | 1.39 (1.02, 1.90) | 226 | 138 | 1.21 (0.91, 1.60) | 1.26 (1.08, 1.47) |
| Lagtime4 | ||||||||||
| ≤10yrs | 178 | 143 | 1.15 (0.88, 1.50) | 146 | 108 | 1.42 (1.02, 1.99) | 203 | 117 | 1.28 (0.96, 1.72) | 1.26 (1.07, 1.48) |
| >10yrs | 34 | 19 | 1.69 (0.91, 3.14) | 39 | 26 | 1.28 (0.71, 2.28) | 23 | 21 | 0.79 (0.41, 1.53) | 1.26 (0.89, 1.78) |
| P trend5 | 0.076 | 0.075 | 0.43 | 0.006 | ||||||
| Diabetes | ||||||||||
| No | 801 | 821 | 1.00 | 463 | 458 | 1.00 | 678 | 519 | 1.00 | 1.00 |
| Yes | 78 | 65 | 1.11 (0.77, 1.61) | 53 | 44 | 1.10 (0.68, 1.77) | 93 | 60 | 1.18 (0.81, 1.73) | 1.20 (0.95, 1.50) |
| Lagtime4 | ||||||||||
| ≤10yrs | 53 | 50 | 0.98 (0.64, 1.50) | 31 | 28 | 0.99 (0.55, 1.77) | 64 | 45 | 0.97 (0.63, 1.51) | 1.04 (0.80, 1.36) |
| >10yrs | 25 | 15 | 1.55 (0.78, 3.06) | 22 | 16 | 1.32 (0.63, 2.78) | 29 | 15 | 1.95 (0.97, 3.93) | 1.63 (1.10, 2.41) |
| P trend5 | 0.36 | 0.55 | 0.16 | 0.033 | ||||||
| 3 conditions3 | ||||||||||
| None | 513 | 583 | 1.00 | 241 | 270 | 1.00 | 352 | 308 | 1.00 | 1.006 |
| 1 | 282 | 239 | 1.13 (0.89, 1.42) | 169 | 168 | 1.02 (0.73, 1.41) | 258 | 188 | 1.20 (0.91, 1.58) | 1.12 (0.96, 1.30) |
| 2 | 69 | 57 | 0.99 (0.65, 1.49) | 92 | 51 | 1.60 (1.01, 2.54) | 130 | 70 | 1.42 (0.97, 2.07) | 1.42 (1.13, 1.78) |
| 3 | 16 | 7 | 1.64 (0.62, 4.33) | 14 | 13 | 1.02 (0.42, 2.45) | 31 | 13 | 1.88 (0.90, 3.93) | 1.62 (1.02, 2.57) |
| P trend5 | 0.41 | 0.17 | 0.021 | 0.001 | ||||||
| Any condition | 367 | 303 | 1.11 (0.89, 1.39) | 275 | 232 | 1.12 (0.83, 1.53) | 419 | 271 | 1.28 (0.99, 1.64) | 1.19 (1.03, 1.37) |
| 2 or 3 conditions | 85 | 64 | 1.06 (0.71, 1.56) | 106 | 64 | 1.49 (0.96, 2.30) | 161 | 83 | 1.48 (1.04, 2.13) | 1.45 (1.16, 1.80) |
| Yes treatment | 239 | 191 | 1.04 (0.80, 1.37) | 183 | 165 | 1.01 (0.71, 1.43 | 330 | 203 | 1.32 (1.00, 1.74) | 1.15 (0.98, 1.36) |
| No treatment | 128 | 112 | 1.21 (0.90, 1.63) | 92 | 67 | 1.32 (0.89, 1.97) | 89 | 68 | 1.19 (0.81, 1.74) | 1.24 (1.02, 1.51) |
Adjusted for age, education, income, years of residence in the US among non-US born, interviewer, family history of breast cancer, benign breast diseases, parity, age at menarche, age at and type of menopause, education and body mass index.
As above and also adjusted for Asian ethnicity,
Included HBP, high cholesterol, and diabetes. Yes treatment means for any 1 of the 3 conditions; no treatment means no for all 3 conditions.
Lagtime is defined as years between first diagnosis of metabolic condition and breast cancer diagnosis.
For the p trend analyses, the baseline group comprised those with no metabolic condition.
There were no changes in ORs with further adjustment for alcohol intake (never, former and current) for none, 1, 2, 3 conditions combined (ORs were 1.00, 1.12 (0.96, 1.30), 1.42 (1.13, 1.78) and 1.62 (1.02, 2.57), respectively).