Figure 5:

Measurements of pain recorded in mice during optogenetic inhibition of the left or right CeA. Optogenetic inhibition (with halorhodopsin) of the left CeA caused an increase in bladder pain suggesting an on-going anti-nociceptive output from the left CeA in naive mice. Left CeA effects are statistically significantly different from right CeA optogenetic inhibition (t-test P = 0.013; n = 8 − 9) and significantly different from baseline (onesample t-test compared to hypothetical value of 100% (pink dotted line); P = 0.029). In contrast, optogenetic inhibition of the right CeA did not significantly change bladder pain-like effects compared to baseline (one sample t-test compared to hypothetical value of 100%; P = 0.53). Error bars represent mean ±1 standard error. Data adapted from Sadler et al. [45].