Table 4. Risk factors for clinical indicators of adrenal insufficiency.
| Variable | Hazard ratios and 95% CIs |
|---|---|
| Sex | |
| Women | 1 |
| Men | 0.99 (0.92–1.07) |
| Age, y | |
| < 30 | 1 |
| 30–49 | 1.24 (0.95–1.63) |
| 50–69 | 1.80 (1.41–2.32) |
| ≥70 | 3.00 (2.35–3.82) |
| Average daily dose in prednisolone equivalents | |
| < 5 mg /day | 1 |
| 5–9 mg/day | 1.13 (1.02–1.25) |
| 10–20 mg/day | 1.76 (1.59–1.94) |
| 20 + mg/day | 3.28 (2.89–3.73) |
| Treatment duration | |
| < 6 months | 1 |
| 6–12 months | 1.12 (1.01–1.24) |
| 1–2 years | 1.03 (0.92–1.16) |
| > 2 years | 1.21 (1.07–1.36) |
| Cumulative dose in prednisolone equivalents | |
| < 0.5 g | 1 |
| 0.5-5g | 1.25 (1.10–1.41) |
| 5+ g | 2.06 (1.81–2.34) |
| Use of antibioticsa | |
| No | 1 |
| Yes | 1.83 (1.64–2.05) |
a Proxy for infection. The antibiotic prescription had to be redeemed up to 30 days prior to an event to count as a precipitating factor (modelled as a time-varying exposure)