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Change from baseline in HAM-D single items at week 6/8 (FAS, MMRM, SES) – all five studies (Alvarez et al., 2012; Baldwin et al., 2012b; Henigsberg et al., 2012; Jain et al., 2013; Mahableshwarkar et al., 2013). *p<0.05; **p<0.01; ***p<0.001. Definition of each item provided in Table 2.
