TABLE I.

Administration of trastuzumab, by route and breast cancer (BCa) status^a

Dose	Intravenous			Subcutaneous
	Early BCa		Metastatic BCa 3-Weekly	Early BCa 3-Weekly	Metastatic BCa 3-Weekly
	Weekly	3-Weekly
Loading	4 mg/kg over 90 min	8 mg/kg over 90 min	8 mg/kg over 90 min	None	None
Maintenance
First	2 mg/kg over 90 min	6 mg/kg over 90 min	6 mg/kg over 90 min	600 mg over 2–5 min given in the thigh (alternating left and right)
Subsequent	2 mg/kg over 30 min	6 mg/kg over 30 min	6 mg/kg over 30 min

^aAdapted from European Medicines Agency, 2010¹⁰.