TABLE II.

Administration technique for subcutaneous trastuzumab

Factor	Approach
Patient education	▪ Educate patient on clothing selection to increase comfort and privacy.
Injection site	▪ Alternate between left and right thigh to maximize drug exposure (based on GAIN-2 trial). ▪ Give at least 2.5 cm from the old site and never inject into areas where the skin is red, bruised, tender, or hard. ▪ Ensure that other products for subcutaneous administration are injected into different sites during the course of treatment.

^aAdapted from European Medicines Agency, 2010¹⁰.