TABLE VIII.

Comparison of the subcutaneous (SC) and intravenous (IV) formulations of trastuzumab

Factor	Formulation
	Subcutaneous	Intravenous
Dosing	▪ No IV bag preparation ▪ No preparatory compounding needed ▪ Ready-to-use vial ▪ Fixed dose requiring no calculations ▪ No loading dose required	▪ IV bag preparation ▪ Bodyweight-based dosing calculations might increase errors ▪ Loading dose required
Wastage	▪ None	▪ Potential leftovers in vial
Administration	▪ About 2–5 minutes ▪ Less pain, discomfort, bruising for patients ▪ Greater vein preservation because of lack of need for IV catheter ▪ Potential repetitive injuries and back strain with large-volume injections ▪ Patient privacy and clothing related to thigh injections ▪ Increased availability of infusion chairs	▪ About 30–90 minutes ▪ More pain, discomfort, bruising for patients ▪ IV catheter placement errors ▪ Fewer infusion chairs available
Safety	▪ More injection site reactions or administration-related reactions	▪ Slightly better safety profile
Chair time	▪ 55–57 Minutes shorter for SC
Health care practitioner time	▪ 13–17 Minutes shorter for SC