Table 1.

Studies evaluating hypertensive patients with coronary artery disease

	Study Design	Patient Population	Systolic Blood Pressure	Diastolic Blood Pressure
INVEST [10, 40]	Observational / Post hoc analysis	Patients age >50 years with established coronary artery disease	Tight control (<130 mmHg) was not associated with improved cardiovascular outcomes as compared to usual control (between 130-140 mmHg); Usual control as compared to uncontrolled SBP (>140 mmHg) was associated with improved outcomes	DBP <70-80 mmHg is associated with increased mortality in patients with SBP is between 110-120 mmHg, as compared to patients with SBP between 120-140 mmHg
CLARIFY [41]	Observational / Post hoc analysis	Patients with known stable coronary artery disease	SBP <120 mmHg or SBP >140 mmHg was associated with increased mortality and adverse cardiovascular outcomes	DBP <70 mmHg or DBP >80 mmHg was associated with increased mortality and adverse cardiovascular outcomes
VALUE [35,57]	Randomized Controlled Trial	Patient population with risk factors for cardiovascular disease and those with established coronary artery disease (~50% of cohort)	Achieving SBP <140 mmHg was associated with significant benefits in terms of combined cardiac events, myocardial infarction, stroke, and mortality	No differences in cardiovascular morbidity between patients with DBP <70 mmHg as compared to those with DBP >70 mmHg
ARIC [39]	Observational / Post hoc analysis	Patients with risk factors of cardiovascular disease but without prior established cardiovascular disease or heart failure		In patients with SBP >120 mmHg, lowering DBP below 70 mmHg and particularly below 60 mmHg, was associated with increased incidence of coronary events and mortality

ACCORD [31,32] and SPRINT [33] included patients who were at high risk for cardiovascular events along with some patients with known coronary artery disease. However, neither of these studies reported findings specifically for patients with known coronary artery disease.