Skip to main content
. Author manuscript; available in PMC: 2020 Mar 15.
Published in final edited form as: Biol Psychiatry. 2018 Oct 9;85(6):517–526. doi: 10.1016/j.biopsych.2018.09.026

Figure 1. MDD-related changes in BDNF transcript variants and synaptic markers in human dlPFC.

Figure 1.

(A) Relative expression level (MDD/control) of BDNF transcripts, (B)NTRK2 isoforms, and (C-E) selected synapse-related genes (n=19 subjects/group). BDNF EXON1 and 4 are associated with localization in soma and proximal dendrite. BDNF EXON2, 6 and L-3’-UTR are associated with localization in distal dendrites.(F) Pearson’s correlation between BDNF L-3’-UTR and SST, and PVALB. BDNF L-3’-UTR is positively correlated with SST, a dendritic targeting interneuron marker, but not with PVALB, a marker of perisomatic targeting interneurons. (G) Overall correlation between BDNF L-3’- UTR and MDD-affected or unaffected synaptic markers. Significant positive correlations between BDNF L-3’-UTR level and MDD-associated gene expression changes suggest a contribution of dendritic BDNF to transcriptome alterations. *, p<0.05; **, p<0.01; ***, p<0.001. Data are represented as mean ± SEM.

HHS Vulnerability Disclosure