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. Author manuscript; available in PMC: 2020 Mar 15.
Published in final edited form as: Biol Psychiatry. 2018 Oct 9;85(6):517–526. doi: 10.1016/j.biopsych.2018.09.026

Figure 2. Chronic stress-related changes of anxiety-/depressive-like behaviors and expression of Bdnf transcript variants and Sst in mouse mPFC.

Figure 2.

(A) Stress-associated behavioral change in the cookie test (increased latency to bite cookie), (B) novelty suppressed feeding (increased latency to bite food pellet). (C) Increased depressive-/anxiety-like phenotype in stressed mice compared to controls. (D) Relative expression level (stress/control) of Bdnf transcript variants. (E) Positive correlation between Bdnf L-3’-UTR and Sst suggests a functional link between the two genes in mouse brain. (F) Behavioral emotionality was negatively correlated to Bdnf L-3’-UTR (left) and Sst (right). n=12/group; *p<0.05, **p<0.01. Data are represented as mean ± SEM.