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. Author manuscript; available in PMC: 2020 Mar 15.
Published in final edited form as: Biol Psychiatry. 2018 Oct 9;85(6):517–526. doi: 10.1016/j.biopsych.2018.09.026

Figure 4. Effect of Bdnf L-3’-UTR knockdown and chronic stress on behavior.

Figure 4.

(A) Representative image of GFP expression following AAV injection in mPFC. The mouse mPFC map is from Paxinos and Franklin’s the mouse brain in stereotaxic coordinates (66). C: Cingulate cortex, PL: Prelimbic cortex, IL: Infralimbic cortex). (B) Schematic of the experimental design. (C) No body weight changes by chronic stress. (D) Progressive coat state changes with stress exposure. (E) shRNA-treated mice spent less time in the center of the open field apparatus after UCMS. (F) shRNA-treated mice group showed significantly higher emotionality z-scores than control after stress exposure (scrambled: n=9, shRNA: n=13; *p<0.05, **p<0.01, ***p<0.001). Data are represented as mean ± SEM.