Table 6.
Associations between serum concentrations of the four PFAS and self-reporteda high cholesterol and any other cardiovascular condition, assessed using logistic regression modelsb (n=105)
| PFNA | PFOA | PFOS | PFHxSb | All | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| Outcome = High Cholesterol | ||||||||||
| PFAS | ||||||||||
| PFNA | 1.16 | (1.03, 1.29) | 1.10 | (0.94, 1.29) | ||||||
| PFOA | 1.12 | (0.94, 1.35) | 1.03 | (0.94, 1.14) | ||||||
| PFOS | 1.10 | (0.99, 1.22) | 1.08 | (0.94, 1.24) | ||||||
| PFHxSc | 1.07 | (0.99, 1.16) | 1.04 | (0.96, 1.13) | ||||||
| Age | 1.03 | (0.99, 1.06) | 1.03 | (1.00, 1.07) | 1.03 | (0.99, 1.07) | 1.07 | (1.02,1.12) | 1.05 | (0.99, 1.10) |
| BMI | 0.96 | (0.90, 1.03) | 0.98 | (0.92, 1.04) | 0.99 | (0.92, 1.05) | 1.01 | (0.93,1.10) | 0.99 | 0.91, 1.09) |
| Outcome = Other Cardiovascular Conditions | ||||||||||
| PFAS | ||||||||||
| PFNA | 1.04 | (0.93, 1.17) | 1.05 | (0.89, 1.25) | ||||||
| PFOA | 0.97 | (0.90, 1.05) | 0.95 | (0.84, 1.08) | ||||||
| PFOS | 1.08 | (0.98, 1.21) | 1.10 | (0.95, 1.27) | ||||||
| PFHxSc | 1.02 | (0.94,1.10) | 1.00 | (0.92, 1.09) | ||||||
| Age | 1.07 | (1.03, 1.12) | 1.08 | (1.04, 1.13) | 1.07 | (1.03, 1.11) | 1.10 | (1.05,1.16) | 1.09 | (1.03, 1.15) |
| BMI | 1.09 | (1.02, 1.18) | 1.10 | (1.02, 1.18) | 1.11 | (1.03, 1.19) | 1.14 | (1.04,1.25) | 1.15 | (1.04, 1.28) |
a
All health outcomes are self-reported as a positive response to the question “Have you ever been diagnosed by a doctor with any of the following health conditions?”
b
All variables were entered as continuous variables
c
PFHxS was entered all models in the quadratic form