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. Author manuscript; available in PMC: 2020 Feb 1.

Published in final edited form as: Circ Genom Precis Med. 2019 Feb;12(2):e002328. doi: 10.1161/CIRCGEN.118.002328

Figure 1. — A) Mean number of regulatory elements overlapping with QRS-associated loci (red circle) compared with 10,000 matched control sets (gray bars). Differentially acetylated / regulated elements in HCM show more enrichment (p=8.6e-5) for QRS-associated candidate causal variants than those not showing differential activity (p=0.01). B) Promoters of genes differentially regulated between HCM patients and controls showed more enrichment (p=0.001) for QRS-associated variants than differentially acetylated enhancers (p=0.8) and super-enhancers (p=0.025).

Figure 1. — A) Mean number of regulatory elements overlapping with QRS-associated loci (red circle) compared with 10,000 matched control sets (gray bars). Differentially acetylated / regulated elements in HCM show more enrichment (p=8.6e-5) for QRS-associated candidate causal variants than those not showing differential activity (p=0.01). B) Promoters of genes differentially regulated between HCM patients and controls showed more enrichment (p=0.001) for QRS-associated variants than differentially acetylated enhancers (p=0.8) and super-enhancers (p=0.025).