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Blinded-rater assessment of aesthetic improvements in the submental region using the Merz Aesthetic Scale (MAS). Responders were defined as the proportion of subjects who showed at least one point of improvement on the validated MAS (4 = very severe, 3 = severe, 2 = moderate, and 1 = mild skin sagging). Week 12: microfocused ultrasound with visualization (MFU-V). Weeks 24 and 48: MFU-V and additional calcium hydroxylapatite injections to the jawline at week 12
