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. 2019 Feb 13;7:23. doi: 10.3389/fchem.2019.00023

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Copyright © 2019 Geranurimi, Cheng, Quiniou, Zhu, Hou, Rivera, St-Cyr, Beauregard, Bernard-Gauthier, Chemtob and Lubell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of peptides 1, 5, and 6 on IL-1-induced NF-κB signaling. NF-κB activation was quantified on HEK-blue cells using the QUANTI-blue assay, which spectroscopically detects secreted alkaline phosphatase, a reporter product from the transcription of the NF-κB gene. HEK-blue cells were pre-incubated with peptides 1, 5, and 6 or vehicle, then stimulated with IL-1β for 4 h. Data shown represents the average of 3 experiments, each with n = 4 per treatment group. ^****p < 0.0001 compared to group treated only with IL-1β. Treatment groups that are not labeled with asterisks are statistically non-significant compared to group treated only with IL-1β.