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. 2019 Feb 13;7:23. doi: 10.3389/fchem.2019.00023

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Copyright © 2019 Geranurimi, Cheng, Quiniou, Zhu, Hou, Rivera, St-Cyr, Beauregard, Bernard-Gauthier, Chemtob and Lubell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of peptides 1, 5, and 6 on IL-1β-induced phosphorylation of JNK, ROCK2, and p38. Graphical representations of band density analysis of Western Blots, sorted into columns based on protein of interest (JNK, ROCK2, or p38) and rows by peptide configuration [(3R-) or (3S)]. RAW-blue cells were pretreated with peptides 1, 5, 6, Kineret, or vehicle for 30 min and then stimulated with IL-1β for 15 min. Images of representative Western Blots can be found in the Supplementary Figure 1. Results shown are the average of 3 independent experiments: ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001 compared to group treated only with IL-1β. Treatment groups that are not labeled with asterisks are statistically non-significant compared to group treated only with IL-1β.