Figure 1.

Body weight, survival and human blood cell reconstitution in huNSG and huSGM3 mice with or without human thymus. NSG or SGM3 mice were transplanted with human CD34⁺ cells alone or along with human fetal thymus tissue (n = 4 per group). (A) Body weight changes in the indicated groups of humanized mice between 14 and 20 weeks after transplantation. Body weight at 14 weeks was used as baseline value. (B) Survival of humanized mice after transplantation. (C) Levels (%) of human CD45⁺ cell chimerism in WBCs at the indicated time points after transplantation. (D–E) Kinetics of the frequencies of human CD33⁺ myeloid (D) and CD3⁺ T cells (E) within human CD45⁺ cells. For (A,C–E), repeated measures analysis of variance was used to determine main effects (P < 0.05) between groups. All of the panels had main effects, and post-hoc Bonferroni was used to compare groups at each time point. For p < 0.05 for post-hoc test are indicated as *, #, $, or & for group comparisons indicated in the legend. Error bars represent SEMs.