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. 2019 Feb 13;13:88. doi: 10.3389/fnins.2019.00088

FIGURE 1.

FIGURE 1

Ox1R blockade or GABAergic inhibition within medial NAc Shell significantly reduced alcohol drinking in mice. (A) Intra-Shell infusion of the Ox1R inhibitor SB reduced alcohol intake in the 2bc-DID model, replicating previous studies (Lei et al., 2016b). For this and all other bar graphs, open bar is with vehicle injection, shaded bar is with drug injection, tested within-animal. (B) Intra-Shell SB reduced alcohol intake in the 2bc-IA. (C) Global inhibition of Shell with GABA receptor agonists muscimol/baclofen significantly reduced 2bc-DID alcohol intake. (D) Ox1R inhibition in Core did not significantly reduce 2bc-DID alcohol drinking. Shell Ox1R blockage did not alter concurrent water intake in 2bc-DID (E) or 2bc-IA (F); water intake indicated by cross-hatching. (G) Shell GABA-mediated inhibition did not alter concurrent water intake in 2bc-DID. M/B, muscimol/baclofen; SB, SB-334867. ∗p < 0.05, ∗∗p < 0.01.