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. 2019 Feb 19;9:2317. doi: 10.1038/s41598-018-36492-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Surface property analysis of preferable binding poses for KCF18 to proinflammatory cytokines. KCF18 is represented as an orange-colored and green-colored loop structure. Residues around the binding interface are labeled and are shown as sticks. Surface charge distribution of KCF18 binding to cytokines was calculated using the Poisson–Boltzmann equation. Blue color corresponds to positive and red color to negative electrostatic potential. (A) KCF18–TNF-α, (C) KCF18–IL-1β, and (E) KCF18–IL-6 complexes. Surface lipophilicity distribution of KCF18 binding to cytokines, in which blue color represents hydrophilic residues, whereas green color represents hydrophobic residues. (B) KCF18–TNF-α, (D) KCF18–IL-1β, and (F) KCF18–IL-6 complexes.