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. 2019 Feb 19;9:2247. doi: 10.1038/s41598-019-38911-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effects of compound 8 on the sub-acute PD mouse model induced by MPTP. Mice were injected with MPTP hydrochloride (30 mg/kg, i.p.) for 5 consecutive days; compound 8 (50 mg/kg), 3-HM (50 mg/kg) or L-DOPA (20 mg/kg) were administered 30 min before each MPTP injection, and administration continued for the next 7 days. Compound 8 improved motor behaviour of mice, as measured by (A) rotarod test and (B) pole test (n = 15). (C,D) TH-positive staining neurons. Representative sections of substantia nigra from 5 mice are shown. Data were the mean ± SEM; **P < 0.01 versus control mice; ^#P < 0.05, ^##P < 0.01 versus MPTP–injected mice.