Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 19;9:2249. doi: 10.1038/s41598-019-38680-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Amino-acid sequence alignment of ALACM and three kinds of visualization of non-mutated and mutated ALACM. (a) Altered amino acids at p259 and p297 are shown in non-mutant and mutant ALCAM protein models. (b) In the surface of non-mutant and mutant ALCAM, mutation sites of p259 and p297 are colored as blue and red, respectively. (c) Electrostatic potential maps on the surface of p259 and p297 residues. Compared with non-mutant ALCAM, the p259 mutation in mutant ALCAM shows a trend of negatively charged region, while p297 mutation tends to be neutral (blue: positive charges; red: negative charges). (d) Two missense mutations in ALCAM were marked within rectangle. The asterisk means all species have the same amino acid type at this position. Species in red are owls; species in green are other birds; species in blue are mammals; species in black is a reptile.