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. 2019 Feb 20;11(1):2. doi: 10.1038/s41368-018-0036-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — AFM mechanical scanning images of TMJ discs. a–c Representative nanomechanical mapping features of discs from the control group. Magnitude of Young’s modulus was consistent with the collagen D-period banding. d–f Representative nanomechanical mapping features of discs from the inflamed group. Compared with the control group, the inflamed samples exhibited a decreased magnitude and disordered distribution of Young’s modulus. g Nonparametric tests of collagen fibril diameter distribution based on three rats per group. The box presents 5%, lower quartile, median, higher quartile and 95%. The inflammation group exhibited significant differences in Young’s modulus compared with the control group. **P < 0.01, scale bar: 400 nm