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. 2019 Feb 19;9:2314. doi: 10.1038/s41598-018-38294-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cone abnormalities by P21 in Dicer CKO mice. (A–D) Immunostaining for CA of P21 control (A,C) and Dicer CKO (B,D) peripheral and central retinas. White arrows indicate normal wild type segments. Yellow arrows indicate abnormal short segments (E) Quantification of CA^+ve cone photoreceptors. (F) Measurement of the ONL thickness. (G) Average length of CA^+ve segments (IS + OS). (H) Graph showing the percentage of cones displaying long (>20 μm), medium (10–19.99 μm) and short segments (<10 μm) in control and Dicer CKO peripheral and central retinas. (I–L) Immunostaining for the cone outer segment marker LM OPSIN. OS: outer segments. IS: inner segments. ONL: outer nuclear layer. INL: inner nuclear layer. OPL: outer plexiform layer. GCL: ganglion cell layer. CA: cone arrestin. *Indicates p-value < 0.05. Mann-Whitney non parametric test was used. Error bars indicate standard error of the mean. Scale bar: 30 μm. Scale bar of insets: 10 μm.